JAAGSIEKTE RETROVIRUSES Meaning and
Definition
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Jaagsiekte retroviruses, often abbreviated as JSRVs, are a group of viruses belonging to the retrovirus family. These viruses are primarily associated with a lung tumor condition known as Jaagsiekte, which affects primarily sheep and goats. The term "Jaagsiekte" translates to "chasing sickness" in Afrikaans, referencing the clinical signs observed in affected animals.
JSRVs have a single-stranded RNA genome and are classified under the genus Betaretrovirus. They are known for their ability to integrate their genetic material into the DNA of the host's cells, allowing for long-term persistence and replication within the infected animal's body.
Infection with JSRVs typically occurs through inhalation of respiratory secretions or aerosolized virus particles. Once inside the host, the viruses primarily target the cells lining the airways of the lungs. JSRVs induce the formation of tumors in the lungs, causing significant damage to the respiratory system and leading to severe respiratory distress and ultimately death in affected animals.
The oncogenic properties of JSRVs mainly result from the expression of the viral envelope protein, which can stimulate the uncontrolled proliferation of lung epithelial cells that ultimately develop into tumors. These tumors can vary in size and distribution throughout the lungs and may lead to secondary infections and pneumonia.
Extensive research has been conducted on JSRVs due to their notable impact on the livestock industry and potential zoonotic potential. Understanding the molecular mechanisms behind JSRV infection and tumorigenesis is essential for developing strategies to control the transmission and manage the disease in affected animals.
Common Misspellings for JAAGSIEKTE RETROVIRUSES
- haagsiekte retroviruses
- naagsiekte retroviruses
- maagsiekte retroviruses
- kaagsiekte retroviruses
- iaagsiekte retroviruses
- uaagsiekte retroviruses
- jzagsiekte retroviruses
- jsagsiekte retroviruses
- jwagsiekte retroviruses
- jqagsiekte retroviruses
- jazgsiekte retroviruses
- jasgsiekte retroviruses
- jawgsiekte retroviruses
- jaqgsiekte retroviruses
- jaafsiekte retroviruses
- jaavsiekte retroviruses
- jaabsiekte retroviruses
- jaahsiekte retroviruses
- jaaysiekte retroviruses
- jaatsiekte retroviruses
Etymology of JAAGSIEKTE RETROVIRUSES
The word "Jaagsiekte" comes from Afrikaans, which is a language spoken predominantly in South Africa. "Jaagsiekte" literally translates to "chasing sickness" in English. The term was coined based on the behavior of animals affected by the disease, specifically sheep. Infected sheep exhibit abnormal behavior, such as running excessively or chasing after other members of the flock.
"Retroviruses" refers to a family of viruses that have a unique genetic makeup. These viruses possess RNA as their genetic material instead of DNA, and they have an enzyme called reverse transcriptase. This enzyme allows the retroviruses to convert their RNA into DNA once they infect a host cell. The term "retro" in "retroviruses" refers to this reverse transcription process.
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