AMYLOID PROTEIN PLAQUE Meaning and
Definition
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Amyloid protein plaque refers to the accumulation of abnormal protein fragments known as amyloid proteins within the tissues of various organs in the body, particularly in the brain. Specifically, amyloid plaques are insoluble and characteristic beta-pleated sheet aggregates of the amyloid protein, most commonly associated with neurodegenerative disorders such as Alzheimer's disease.
These plaques are formed when proteins, such as amyloid-beta or tau, misfold and clump together, resulting in the formation of dense deposits. The accumulation of amyloid protein plaques in the brain eventually leads to the destruction of brain cells and disruption of normal neuronal function. This process is often correlated with the development of symptoms like memory loss, cognitive decline, and overall deterioration of mental abilities.
The presence of amyloid plaques can be detected through various technologies such as positron emission tomography (PET) scans and biomarker analysis. These plaques are considered a hallmark of several neurodegenerative disorders, particularly Alzheimer's disease. However, it is important to note that not all individuals with amyloid plaques will develop symptoms of cognitive decline or dementia, as the presence of these plaques may not always directly translate into neurodegeneration.
Research efforts and therapeutic interventions in the field of neurodegenerative disorders often focus on targeting and reducing the accumulation of amyloid protein plaques in order to potentially slow down or prevent disease progression.
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